http://joshualevy.pbwiki.com/ RecentChanges for joshualevy en http://joshualevy.pbwiki.com/feedlogo.gif http://pbwiki.com/ PBwiki 1.3.8 support@pbwiki.com http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-08-26 2008-09-09 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
Completed Phase II: CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
Osiris, <!--raw1Tag--><!--verbatim2--><!--/raw1Tag-->, <!--raw1Tag--><!--verbatim11--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod):]]> Tue, 09 Sep 2008 10:16:53 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Completed Phase II: CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
Osiris, <!--raw1Tag--><!--verbatim2--><!--/raw1Tag-->, <!--raw1Tag--><!--verbatim11--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
In Phase I: Federico Gomez Children's Hospital, Montpellier Medical School, <raw escaped="1">ReNuron (was AmCyte), King's/Bristol, Univ. of Florida, University of Sao Paulo (Burt), Swedish Study, Bayhill Theraputics: BHT 3021, Joslin (Orban): IBC-VS01
2006-07-18: Transition aims to begin a Phase 1 clinical study by year-end.
(Pescovitz: Rituximab)
wikipediaentry
clinicaltrials.govrecord
NIAID/ITN (Gitelman: Thymoglobulin / ATG)
]]> Thu, 28 Aug 2008 17:07:49 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Completed Phase II: CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
Osiris, <!--raw1Tag--><!--verbatim2--><!--/raw1Tag-->, <!--raw1Tag--><!--verbatim11--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
In Phase I: Federico Gomez Children's Hospital, Montpellier Medical School, <raw escaped="1">ReNuron (was AmCyte), King's/Bristol, Univ. of Florida, University of Sao Paulo (Burt), Swedish Study, Bayhill Theraputics: BHT 3021, Joslin (Orban): IBC-VS01
2006-09-19: More data from previous Phase II study: http://www.diamyd.com/docs/PressClip.aspx?PageID=10&LangID=2&ClipID=312&sm=b_b
2005-10-12: Company has requested end of Phase II meeting with FDA to plan Phase III: Source
Andromeda "Diapep 277"
Venture Capital Funded, not publicly tra]]> Wed, 27 Aug 2008 09:42:48 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-08-25 2008-08-26 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
Completed Phase II: CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
Osiris, <!--raw1Tag--><!--verbatim2--><!--/raw1Tag-->, <!--raw1Tag--><!--verbatim11--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod):]]> Wed, 27 Aug 2008 09:41:31 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials UpdateMarch2007 (Under Construction)
Summary of Status
GAD65, DeveloGen: ~Andromeda: DiaPep 277, and ToleRx: otelixizumab
Completed Phase II: CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
Osiris, <!--raw1Tag--><!--verbatim2--><!--/raw1Tag-->, <!--raw1Tag--><!--verbatim11--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
In Phase I: Federico Gomez Children's Hospital, Montpellier Medical School, <raw escaped="1">ReNuron (was AmCyte), King's/Bristol, Univ. of Florida, University of Sao Paulo (Burt), Swedish Study, Bayhill Theraputics: BHT 3021, Joslin (Orban): IBC-VS01
Update to LCT
Update to TolerRx
Update to P227
2008-07
Update to NovoCell
2006-09-19: More data from previous Phase II study: http://www.diamyd]]> Wed, 27 Aug 2008 09:33:21 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials Summary of Status
Started Phase III: Diamyd: GAD65, DeveloGen: DiaPep 277, and ToleRx: otelixizumab
II: CBCTD</p>
<p>Some CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.</p>
<p>In E1-I.N.T.
In Phase II: Osiris, <!--raw1Tag-->MacroGenics, <!--raw1Tag--><!--verbatim12--><!--/raw1Tag-->, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
Some results from Phase I:
InIn Phase I: Federico Gomez Children's Hospital, Montpellier Medical School, ReNuron <raw escaped="1">ReNuron (was AmCyte), King's/Bristol, Univ. of Florida, University of Sao Paulo (Burt), Swedish Study, Bayhill Theraputics: BHT 3021, Joslin (Orban): IBC-VS01
Planning for Phase I: all the rest
(M]]> Tue, 26 Aug 2008 21:50:04 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials Completed Phase II: CBCTD</p>
<p>Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.</p>
II: Osiris, <!--raw1Tag-->MacroGenics, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
Some results from Phase I:
"Researchers then combine the dendritic cells with specific blockers of molecules, known as CD40, CD80 and CD86, all of which can be synthesized in a laboratory. This treatment strategy was found to inhibit the interaction and destructive effect of T cells on the insulin-producing beta cells of the pancreas, a process that is known to be a critical part of how diabetes occurs."
ClinicalTrails
2008-08-25: Phase I scheduled to finish end of 2007, Phase II to start 2008. See this newsarticle
2008-04-28: Phase I started 2007-03, and is expected to end 2008-05. This trial will use 15 people for 1 year.
2006-11-28: Phase I sta]]> Tue, 26 Aug 2008 20:43:35 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Summary of Status
Started Phase III: Diamyd: GAD65, DeveloGen: DiaPep 277, and ToleRx: otelixizumab
II: CBCTD
Some CBCTD</p>
<p>Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
In E1-I.N.T.</p>
<p>In Phase II: MacroGenics, <!--raw1Tag-->MacroGenics, University of Texas-Health Science Center (Brod): IFN-a, Kinexum, Thymoglobulin
Completed Phase I: LCT
Some results from Phase I:
University of Florida (Umbilical Cord Blood Infusion) Haller and Schatz
clinicaltrails.govrecord
children > > 1 year of age with T1D and stored umbilical cord blood are being be recruited. The cord blood will be infused into the children in the GCRC in an attempt to regenerate pancreatic islet insulin-producing beta cells and improve blood glucose control."
This study is sponsored by JDRF.
Study started: ]]> Tue, 26 Aug 2008 19:21:05 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-07-21 2008-08-25 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
UpdateMarch2007 (Under Construction)
Summary of Status
III: Diamyd, Diamyd: GAD65, DeveloGen: DiaPep 277 277, and ToleRx: otelixizumab
Completed Phase II: TolerRx, CBCTD
Some results from ongoing Phase II: Transition Therapeutics: E1-I.N.T.
In Phase II: MacroGenics, University of Texas-Heal]]> Tue, 26 Aug 2008 19:17:34 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (JoshuaLevy) JoshuaLevy edited DiabetesCureReadyForHumanTrials 3. Does not require a lifetime of immunsuppressive drugs, so it is not trading one treatment for another. (but a couple of operations, or a short course of drugs is OK)
In the past I have excluded research specific to the "honeymoon" phase of the disease, but I have now decided to include human trials which focus on the honeymoon phase. Research by Diamyd, Faustman and others has convinced me that a cure for all diabetics may grow out of a cure for "honeymoon" diabeteics.
them joshualevy@yahoo.com. joshua2levy@yahoo.com.
Note: I do not control the ads you see on the right! They usually involve quack ("homeopathic") cures for type-2 diabetes, and they annoy me, too.
Note Also: I generally don't know anything about any of these trials except what you see here, so please don't email me to ask for more info. Instead, research them yourself on the web. (And if you tell me what you find, I'll add it here. :-)
]]> Tue, 26 Aug 2008 19:10:02 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials 2008-07
Update to NovoCell
Created Osiris Therapeutics
2008-06
Update to Bayhill
"The study was conducted on eighty patients with type 1 diabetes enrolled in Belgium and in Munich (Germany). Patients who received a six-day course of antibody treatment immediately after diagnosis, maintained, over the 18 month follow-up period, a higher insulin production, ie residual beta cell function, than patients who received a placebo. They were found to need lower doses of injected insulin to maintain blood glucose control. This benefit was primarily seen in patients who presented with a less pronounced loss in insulin production at diagnosis. Side effects were minor and short-lived including flu and mononucleosis-like symptoms."
Treatments that have Started Phase-2 Trails
Osiris Therapeutics
(This entry is still under development.)
2008-07-07: Phase II trial started 2008-06 and scheduled to end 2010-06.
2008-06-27: newspaperarticle
USGovClinicalTrialRecord]]> Mon, 21 Jul 2008 22:51:48 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-06-30 2008-07-21 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
Completed Phase I:
Some results from Phase I: LCT
AmCyte), NovoCell, King's/Bristol, Univ. of Florida, University of Sao Paulo (Burt), Swedish Study, Bayhill Theraputics: BHT 3021, Joslin (Orban): IBC-VS01
Planning for Phase I: all the rest
(MGM/Faustman is in phase-1 trials, but not for a type-1 diabetes cure. They are gathering data ]]> Mon, 21 Jul 2008 22:36:28 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials (Pescovitz: Rituximab)
clinicaltrials.govrecord
ThymoglobulinNIAID/ITN (Gitelman: Thymoglobulin / ATG () ATG)
This is a "give drugs quickly during the honeymoon period, and save some beta cells" type treatment.
clinicaltrials.govrecord
]]> Mon, 30 Jun 2008 14:19:06 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials (Pescovitz: Rituximab)
clinicaltrials.govrecord
Thymoglobulin / ATG ()
This is a "give drugs quickly during the honeymoon period, and save some beta cells" type treatment.
clinicaltrials.govrecord
USFpage
ITNpage
"Treatment of new onset type 1 diabetes with Thymoglobulin is therefore expected to alter the behavior of the T cells to halt their attack, and also reduce T cell numbers, so that new T cells that grow in their place will learn to accept the beta cells, rather than attacking them."
2008-03: A phase-2 trial is about to start recruiting. It will have about 66 people (2/3 treated, 1/3 placebo), and last 2 years.
Treatments that have Started Phase-1 Trials
Stony Brook (Wilson: Pioglitazone)
FullProtocolDescription
2004-07: Phase-1 study starts. 180 people divided into three groups: MMF, MMF and DZB and neither MMF or DZB. Expected to last four years.
Thymoglobulin / ATG ()
This is a "give drugs quickly during the honey]]> Mon, 30 Jun 2008 14:15:39 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-06-10 2008-06-30 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
2006-09-14: JDRF has funded this advance this into Phase 2 trials.
2006-07-18: Transition aims to begin a Phase 1 clinical study by year-end.
Treatments that have Started Phase-1 Trials
(Pescovitz: Rituximab)
clinicaltrials.govrecord
Treatments that have Started Phase-1 Trials
Stony Brook (Wilson: Pioglitazone)
clini]]> Mon, 30 Jun 2008 14:08:09 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-06-09 2008-06-10 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
Recent Changes
2008-06
Update to Bayhill
Update to LCT
Update to TolerRx
2006-08-24: application with the New Zealand for Phase I/IIa expected to last about 12 months. No firm start date. http://www.lct.com.au/news/LCT-lodges-application-for-clinical-trial-24-8-06.pdf
Bayhill Theraputics (BHT 3021)
Phase-1http:]]> Tue, 10 Jun 2008 12:30:48 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials Phase-1 study started: 2004-03 and is expected to end 2008-06. Study includes about 100 people, all in the honeymoon phase. Study tests MMF alone, DZB alone, and MMF and DZB together. This research is funded by JDRF amoung others.
ClinicalTrails.govrecord
BGH / Harvard (Nathan/Faustman)
http://www.joslin.org/1083_3312.asp
Dr. Faustman on the research side, Dr. Nathan on the clinical trials.
Combination of "short course" drugs. Used to involve spleen cells, but that part did not pan out.
Funded by "Join Lee Now"
My comments on Faustman's research.
2008-03-14: Phase-1 study has started to test half of the complete solution. However, this is not a test of a cure for type-1: only half a cure. clinicaltrials.govrecord pressrelease
2007-08: Human trials to start sometime in 2008. officialupdate
2006-08: Human trials to start "Fall 2008" although non-human parts will start in 2007.
2006-05: Money to be released before 2006-08, but there is pre-]]> Mon, 09 Jun 2008 14:18:33 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-05-13 2008-06-09 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
2006-05: DiaPep277® has successfully completed phase II clinical rials for the treatment of type 1 diabetes. DeveloGen has started phase III clinical trials in September 2005. Source
2001-11-23: Phase II completed, phase III to start "next year". Source
Tolerrx (TRX4 or ChAglyCD3)
Not publicly traded www.tolerrx.com.
This is an anti]]> Mon, 09 Jun 2008 14:11:27 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua Levy) Joshua Levy edited DiabetesCureReadyForHumanTrials (MGM/Faustman is in phase-1 trials, but not for a type-1 diabetes cure. They are gathering data to see if they can put together a cure, but they have not started testing a cure as yet.)
Recent Changes
2008-06
Update to LCT
Update to TolerRx
2008-05
Update to Seranova
2008-04
Moved many studies from the "Honeymoon" section to the main section.
TolerRX to phase-3 by mid-2008?
Added MMF/DZB study
2008-03
Investing in Eli Lily
Sernova
INGAP / Kinexum
MGM (Faustman)
Diamyd
LCT
New study: Bayhill Theraputics
Alba
Joslin (Orban): IBC-VS01
Thymoglobulin
If you (or your child) was diagnosed with type-1 diabetes before 6 months of age, then you might have a specific varient of type-1 diabetes, for which a cure is being developed, read here: HattersleyCure. This varient is quite different from the more common form of type-1 diabetes, and this cure will not help most type-1 diabetics. If you were diagnosed with type-1 dia]]> Fri, 06 Jun 2008 13:24:53 +0000 mod http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials email.hidden@example.com (Joshua) Joshua edited DiabetesCureReadyForHumanTrials Possible Diabetes Cures Ready For Human Trials
update: 2008-04-28 2008-05-13 (All dates are in YYYY-MM-DD format!)
This is my list of possible cures for type-1 diabetes that are either in human trials or almost ready for human trials. I will try to put in every trial that I learn of, that meets the following criteria:
1. It is a cure for type-1 diabetes, not a treatment for a symptom. (A cure requires blood sugar control without testing and with doctor's visits 4 times a year, or less. Obviously, this is my personal definition of a cure; yours may differ. Any cure must result in an average lifespan close to normal.)
(MGM/Faustman is in phase-1 trials, but not for a type-1 diabetes cure. They are gathering data to see if they can put together a cure, but they have not started testing a cure as yet.)
Recent Changes
2004-042008-05
Update to Seranova
2008-04
Moved many studies from the "Honeymoon" section to the main section. Wed, 14 May 2008 14:25:49 +0000 mod